Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc. is now a US distributor for Nordic-Mubio products

Nordic-MUbio develops and manufactures high quality antibody reagents for use in R&D. All our products are manufactured according to strict ISO 9001 quality guidelines, and our focus is on developing antibodies targetting Cell Adhesion, Nuclear and Cytoskeletal Proteins.

Nordic-MUbio is one of the leading antibody companies developing antibodies for zebrafish research – we currently have over 50 antibodies validated for immunofluorescence in zebrafish.

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Exalpha Biologicals, Inc.

Matrix Metalloproteinase 3 (MMP3)

  • Product Code: X2055M
  • Size: 200 µg
  • Availability: In Stock In Stock
  • Price (USD): $232

Cat #

X2055M		 Quantity:      

Data Sheet

Product Name

Matrix Metalloproteinase 3 (MMP3)

Synonyms

SL-1, Matrix metalloproteinase-3, MMP-3, Transin-1

Host/Source

Mouse

Clone

1B4

Isotype

IgG1

Product Type

Monoclonal Antibody

Reactivity

Human

Applications

ELISA, Western Blot, Immunohistochemistry

Purification

Protein A/G Chromatography

Size

200 µg

Price (USD)

$232

Background

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including Collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

Immunogen

Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the C-terminus of the human MMP3 protein and mouse myeloma Ag8563 cells.

Positive Control

Oesophageal and gastric tissues. Expressed at higher levels in tumor.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

50 kDa (proenzyme)

Product Image

Image Legend

Left: Immunohistochemical staining of human gastric carcinoma tissue using MMP-3 antibody (Cat. No. X2055M). Right: Western blot of recombinant human MMP-3 proenzyme using MMP-3 antibody.

Database Links:

SwissProtP08254Human

References

1. Knauper, V., et al. (1996). Activation of human neutrophil procollagenase by stromelysin 2. Eur. J. Biochem. 235(1-2);187-191

2. Saus, J. et al. (1988). The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin. J. Biol. Chem. 263;6742-6745