Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Matrix Metalloproteinase 2 (MMP2)

  • Product Code: X2054M
  • Size: 200 µg
  • Price (USD): $232

Cat #

X2054M		 Quantity:      

Data Sheet

Product Name

Matrix Metalloproteinase 2 (MMP2)

Synonyms

MMP2; MMP-2; CLG4; CLG4A; Matrix metallopeptidase 2; 72 kDa Type IV collagenase precursor; 72 kDa gelatinase, Gelatinase A

Host/Source

Mouse

Clone

4D3

Isotype

IgG1

Product Type

Monoclonal Antibody

Reactivity

Human

Applications

ELISA, Western Blot, Immunohistochemistry

Purification

Protein A/G Chromatography

Size

200 µg

Price (USD)

$232

Background

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves Collagen Types IV, V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway.

Immunogen

Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the C-terminus of the human MMP2 protein and mouse myeloma Ag8563 cells.

Positive Control

Oesophageal and gastric tissues. Expression higher cancerous tissue versus normal tissues.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

50 kDa (proenzyme)

Product Image

Image Legend

A. Immunohistochemical staining of human oesophageal adenocarcinoma tissue using MMP-2 antibody (Cat. No. X2054M). B. Western blot using MMP-2 antibody on recombinant MMP-2 proenzyme (400 ng/lane).

Database Links:

SwissProtP08253Human

References

1. Talvensaari-Mattila, A., et al. (2005). Prognostic value of matrix metalloproteinase-2 (MMP-2) expression in endometrial endometrioid adenocarcinoma. Anticancer Res. 25(6B);4101-4105. 2. Honkavuori, M., et al. (2007). MMP-2 expression associates with CA125 and clinical course in endometrial carcinoma. Gynecol. Oncol. 104(1);217-221.