Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Cytochrome P450 3A7

  • Product Code: X2048M
  • Size: 200 µg
  • Price (USD): $249

Cat #

X2048M		 Quantity:      

Data Sheet

Product Name

Cytochrome P450 3A7

Synonyms

CYP3A7; CYP450 3A7 (EC 1.14.14.1), CYPIIIA7, P450-HFLA

Host/Source

Mouse

Clone

F19 P2 H2

Isotype

IgG1

Product Type

Monoclonal Antibody

Reactivity

Human

Applications

ELISA, Western Blot, Immunohistochemistry

Purification

Protein A/G Chromatography

Size

200 µg

Price (USD)

$249

Background

CYP3A genes encode monooxygenases, enzymes which catalyze drug metabolism and the synthesis of cholesterol, steroids and other lipids. CYP3A (cytochrome P450, family 3, subfamily A), the most abundant P450 enzyme in human liver, is responsible for the metabolism of more than 50% of all clinical drugs. CYP3A members localize in organs that associate with drug disposition, including the liver, gastrointestinal tract and kidney. The CYP3A cluster consists of four genes: CYP3A43, CYP3A4, CYP3A7 and CYP3A5, and two pseudogenes: CYP3A5P1 and CYP3A5P2. The CYP3A cluster maps to gene locus 7q21.3-q22.1.

Immunogen

Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the C-terminus of the human CYP3A7 protein and mouse myeloma Ag8563 cells.

Positive Control

Prostate cancer

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

61 kDa

Product Image

Image Legend

A. Western blot analysis using CYP3A7 antibody (cat. no. X2048M) on various recombinant CYP450 proteins. B. Immunohistochemistry staining of prostate cancer tissue using CYP3A7 antibody.

Database Links:

SwissProtQ9H241Human

References

1. Kumarakasingham, M., et al. (2005). Cytochrome p450 profile of colorectal cancer: Identification of markers of prognosis. Clin. Cancer Res. 11(10);3758-3765. 2. Leeder, J.S., et al. (2005). Variability of CYP3A7 expression in human fetal liver. J. Pharmacol. Exp. Ther. 314(2);626-635. 3. Ogino, M., et al. (2002). Selective suppressions of human CYP3A forms, CYP3A5 and CYP3A7, by troglitazone in HepG2 cells. 17(1);42-46.