Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Sphingosine Kinase 1, Long Form, Rat

  • Product Code: X2038P
  • Size: 100 µg
  • Price (USD): $258

Cat #

X2038P		 Quantity:      

Data Sheet

Product Name

Sphingosine Kinase 1, Long Form, Rat

Host/Source

Rabbit

Isotype

IgG

Product Type

Polyclonal Antibody

Reactivity

Rat

Applications

Western Blot

Purification

Ammonium Sulfate Precipitation

Size

100 µg

Price (USD)

$258

Background

Rat sphingosine kinase 1 catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (spp)(sphingosine + ATP = sphingosine 1-phosphate + ADP), a lipid mediator with both intra- and extracellular functions. also acts on d-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as d,l-threo-dihydrosphingosine, n,n-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. The long form of sphingosine kinase 1, an N-terminal extension, is responsible for FceRI-mediated calcium mobilization and may play a role in other ligand mediated signaling events.

Immunogen

Synthetic peptide derived from the rat sphingosine kinase 1, long form, protein.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

49843

Product Image

Image Legend

Western blot of rat kidney lysate (10 ug/lane), detection of endogenous Sphingosine kinase 1, long form using X2038P (3 ug/ml), HRP anti-rabbit was used at 1:75k, and developed with Pierce’s Super Signal West Femto.

Database Links:

SwissProtQ1HGK5Rat
GenBankNM_133386Rat

References

1. Venkataraman, K., et al. 'Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient.' Biochem. J., 2006, 397, 461-471

2. Ohotski, J., et al. Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer. Br. J. Can. (2012), 106, 1453-1459