Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

beta Amyloid (Abeta) (N-terminal)

  • Product Code: X1884P
  • Size: 50 µg
  • Price (USD): $698

Cat #

X1884P		 Quantity:      

Data Sheet

Product Name

beta Amyloid (Abeta) (N-terminal)


APP, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA4





Product Type

Antigen Immunoaffinity Purified Polyclonal




Dot Blot, Radio Immunoassay, Enzyme Immunoassay


Purified from rabbit serum by epitope-specific affinity chromatography.


50 µg

Price (USD)



Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity.


Synthetic peptide derived from the N-terminal region of the amyloid beta peptide.

Positive Control

No cross-reactivity against a negative spanning region of A? has been observed by ELISA.


Purified IgG in phosphate buffered saline, pH 7.4

Customer Storage

Product should be stored at -70ºC. Aliquot to avoid freeze/thaw cycles

Database Links:



1. Head, E., Moffat, K., Das, P., Sarsoza, F., Poon, W.W., Landsberg, G., Cotman, C.W., Murphy, M.P. (2005) ?-Amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiol Aging. 26(5): 749-763. 2. Borchelt, D.R. et al. (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19:939-945. 3. Savage, M.J. et al. (1998) Turnover of amyloid ?-protein in mouse brain and acute reduction of its level by phorbol ester. J. Neurosci. 18:1743-1752.