Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery

Product Highlight

Mouse anti-M13 phage coat protein g8p

Antibodies recognising M13 filamentous phage coat proteins are instrumental in the selection and detection of phages expressing specific antibody fragments or peptide sequences at their surface. The monoclonal antibodies manufactured and supplied by Exalpha react with either the pIII (g3p) or pVIII (g8p) proteins of M13 filamentous bacteriophage. All antibodies are available in a purified format. The antibodies are fully validated and are suitable for a wide range of techniques including:

  • ELISA
  • Flow Cytometry
  • Western Blot
  • Immunohistochemistry
  • Immunoprecipitation
For more information, click here for our M13 Bacteriophage information page.

News

Two more of our excellent products have been published by PubMed:

Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis
Borazanci, E., et al., J. Gastrointest. Oncol., 8, 164-172 (2017)
Using Exalpha SPARC Antibody (Cat. No. X1867P)

Molecular mechanism underlying the pharmacological interactions of the protein kinase C-β inhibitor enzastaurin and erlotinib in non-small cell lung cancer cells
Steen, N.V., et al., Am. J. Cancer Res., 7, 816-830 (2017)
Using Exalpha's FITC labeled anti PY20 Antibody (Cat. No. X1017)

Exalpha Biologicals, Inc.

Sphingosine Kinase 1a (mouse recombinant, N-terminal His tag)

  • Product Code: X1850E
  • Size: 10 µg
  • Price (USD): $361

Cat #

X1850E		 Quantity:      

Data Sheet

Product Name

Sphingosine Kinase 1a (mouse recombinant, N-terminal His tag)

Host/Source

Sf9 cells

Product Type

Active Enzyme

Reactivity

Mouse

Applications

Enzyme Kinetic studies, screening inhibitors, selectivity profiling

Size

10 µg

Price (USD)

$361

Background

Sphingolipids have emerged as central signaling molecules regulating a variety of fundamental cell responses such as cell death and differentiation, proliferation and inflammation. Ceramide has been a main focus of research since it possesses pro-apoptotic capacity in many cell types. Sphingosine-1-phosphate (S1P), which is generated from ceramide by the actions of ceramidase and sphingosine kinase can potently induce cell proliferation via binding to and activation of the S1P family of receptors. The balance between ceramide and sphingosine-1-phosphate determines whether cells undergo apoptosis or proliferate, two cell responses that are critically involved in tumor development. The amino acid sequence for sphingosine kionase 1a differs from sphingosine kinase 1 only in the absence of a valine at position 4 of sphingosine kinase 1a.

Immunogen

Baclovirus infected Sf9 cells

Formulation

Provided in 25 mM Tris-HCl, 75 mM NaCl, pH 8.0, 0.05% Tween, 3 mM DTT and 50% glycerol

Customer Storage

Product should be stored at -80°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

47.10

Database Links:

SwissProtAF415213Human

References

1. Delon, C., etal., J. Biol. Chem 279 (43) 44763-44774 (2004)

2. Taha, TA etal., FASEB J. 20(3):482-4 (2005)