Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc. is now a US distributor for Nordic-Mubio products

Nordic-MUbio develops and manufactures high quality antibody reagents for use in R&D. All our products are manufactured according to strict ISO 9001 quality guidelines, and our focus is on developing antibodies targetting Cell Adhesion, Nuclear and Cytoskeletal Proteins.

Nordic-MUbio is one of the leading antibody companies developing antibodies for zebrafish research – we currently have over 50 antibodies validated for immunofluorescence in zebrafish.

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Latest References

Akazawa, Y., et al. "Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis" PLoS ONE 8(12): e82322

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Homa, N.J., et al. "Epstein-Barr Virus Induces Global Changes in Cellular mRNA Isoform Usage That Are Important for the Maintenance of Latency" J. Virol., 2013, 87, 12291-12301

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Exalpha Biologicals, Inc.

Sphingosine Kinase 1a (mouse recombinant, N-terminal His tag)

  • Product Code: X1850E
  • Size: 10 µg
  • Availability: In Stock In Stock
  • Price (USD): $361

Cat #

X1850E		 Quantity:      

Data Sheet

Product Name

Sphingosine Kinase 1a (mouse recombinant, N-terminal His tag)

Host/Source

Sf9 cells

Product Type

Active Enzyme

Reactivity

Mouse

Applications

Enzyme Kinetic studies, screening inhibitors, selectivity profiling

Size

10 µg

Price (USD)

$361

Background

Sphingolipids have emerged as central signaling molecules regulating a variety of fundamental cell responses such as cell death and differentiation, proliferation and inflammation. Ceramide has been a main focus of research since it possesses pro-apoptotic capacity in many cell types. Sphingosine-1-phosphate (S1P), which is generated from ceramide by the actions of ceramidase and sphingosine kinase can potently induce cell proliferation via binding to and activation of the S1P family of receptors. The balance between ceramide and sphingosine-1-phosphate determines whether cells undergo apoptosis or proliferate, two cell responses that are critically involved in tumor development. The amino acid sequence for sphingosine kionase 1a differs from sphingosine kinase 1 only in the absence of a valine at position 4 of sphingosine kinase 1a.

Immunogen

Baclovirus infected Sf9 cells

Formulation

Provided in 25 mM Tris-HCl, 75 mM NaCl, pH 8.0, 0.05% Tween, 3 mM DTT and 50% glycerol

Customer Storage

Product should be stored at -80°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

47.10

Database Links:

SwissProtAF415213Human

References

1. Delon, C., etal., J. Biol. Chem 279 (43) 44763-44774 (2004)

2. Taha, TA etal., FASEB J. 20(3):482-4 (2005)