Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Sphingosine Kinase 2, Long Form

  • Product Code: X1775P
  • Size: 100 µg
  • Price (USD): $355

Cat #

X1775P		 Quantity:      

Data Sheet

Product Name

Sphingosine Kinase 2, Long Form

Synonyms

Sphk2-L, N-terminal-extended Sphingosine Kinase 2

Host/Source

Rabbit

Product Type

Polyclonal Antibody

Reactivity

Human

Applications

ELISA, Western blot

Purification

Ammonium Sulfate Precipitation

Size

100 µg

Price (USD)

$355

Background

The long form of sphingosine kinase 2 (Sphk2-L) is a species-specific isoform of the Sphk2 enzyme expressed in human but not in mouse. It is an N-terminal extended form of Sphk2, extended by 36 amino acids. It functions as expected, catalyzing the formation of sphingosine 1-phosphate from sphingosine, however it appears to have a decreased ability to inhibit DNA synthesis as compared to Sphk2-S (short form of Sphk2). Under normal cellular conditions, Sphk2-L does not appear to inhibit DNA synthesis, but under serum deprivation, SphK2-L translocates to the nucleus and accumlates. This accumlation may be involved in the cessation of cell proliferation or apoptosis depending on the cell type.

Immunogen

Synthetic peptide derived from the N-terminal extension of the Sphk2-L protein.

Positive Control

HEK293 cells

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Database Links:

SwissProtAF245447Human

References

1. Okada, T., et al. 'Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis.' J. Biol. Chem. 2005, 280, 36318-36325