Exalpha Biologicals, Inc.

Latest News

Exalpha Biologicals, Inc. is now a US distributor for Nordic-Mubio products

Nordic-MUbio develops and manufactures high quality antibody reagents for use in R&D. All our products are manufactured according to strict ISO 9001 quality guidelines, and our focus is on developing antibodies targetting Cell Adhesion, Nuclear and Cytoskeletal Proteins.

Nordic-MUbio is one of the leading antibody companies developing antibodies for zebrafish research – we currently have over 50 antibodies validated for immunofluorescence in zebrafish.

Learn More

Latest References

Akazawa, Y., et al. "Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis" PLoS ONE 8(12): e82322

Learn More

Homa, N.J., et al. "Epstein-Barr Virus Induces Global Changes in Cellular mRNA Isoform Usage That Are Important for the Maintenance of Latency" J. Virol., 2013, 87, 12291-12301

Learn More
Exalpha Biologicals, Inc.

Ceramide Glycosyltransferase

  • Product Code: X1700P
  • Size: 100 µg
  • Availability: In Stock In Stock
  • Price (USD): $258

Cat #

X1700P		 Quantity:      

Data Sheet

Product Name

Ceramide Glycosyltransferase

Synonyms

Glucosylceramide synthase, GCS, UDP glucose N-acylsphingosine D glucosyltransferase, GLCT-1, UDP glucose ceramide glucosyltransferase

Host/Source

Rabbit

Isotype

N/A

Product Type

Polyclonal Antibody

Reactivity

Human

Applications

Western Blot, ELISA

Purification

Ammonium Sulfate Precipitation

Size

100 µg

Price (USD)

$258

Background

May serve as a flippase as well as a glucosyltransferase that transfers glucose to ceramide. It Catalzes; UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. Ceramide Glycosyltransferase is the first step in the Glycosphingolipid synthesis; first glycosylation step. Glucosylceramide synthase (GlcT) and lactosylceramide synthase (GalT) are key enzymes for the synthesis of major glycosphingolipids of vertebrates.

Immunogen

Synthetic peptide derived from human ceramide glycosyltransferase protein.

Positive Control

Found in all tissues examined.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

44856

Product Image

Image Legend

Western blot analysis using Ceramide Glycosyltransferase antibody (X1700P) on 7 ug of rat kidney lysate. Antibody used at 1 ug/ml. Visualized using Pierce West Femto substrate system. Secondary used at 1:75k dilution. Exposure for 60 seconds.

Database Links:

SwissProtQ16739Human

References

1. Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis.; Ichikawa S., Sakiyama H., Suzuki G., Hidari K.I.-P., Hirabayashi Y.; Proc. Natl. Acad. Sci. U.S.A. 93:4638-4643(1996).

2. van Vlerken, L.E., et al. ?Modulation of Intracellular Ceramide Using Polymeric Nanoparticles to Overcome Multidrug Resistance in Cancer.? Cancer Res., 67, 4843-4850, (2007).


Product Specific References


This product has been used in:

1. D'Angelo, G., et a, 'Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.' Nature 2007, 449, , 62-67