Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc. is now a US distributor for Nordic-Mubio products

Nordic-MUbio develops and manufactures high quality antibody reagents for use in R&D. All our products are manufactured according to strict ISO 9001 quality guidelines, and our focus is on developing antibodies targetting Cell Adhesion, Nuclear and Cytoskeletal Proteins.

Nordic-MUbio is one of the leading antibody companies developing antibodies for zebrafish research – we currently have over 50 antibodies validated for immunofluorescence in zebrafish.

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Akazawa, Y., et al. "Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis" PLoS ONE 8(12): e82322

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Homa, N.J., et al. "Epstein-Barr Virus Induces Global Changes in Cellular mRNA Isoform Usage That Are Important for the Maintenance of Latency" J. Virol., 2013, 87, 12291-12301

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Exalpha Biologicals, Inc.

MEG-1 (637-926)/PTPN4 N-Terminal GST Tag

  • Product Code: X1661E
  • Size: 20 µg
  • Availability: In Stock In Stock
  • Price (USD): $361

Cat #

X1661E		 Quantity:      

Data Sheet

Product Name

MEG-1 (637-926)/PTPN4 N-Terminal GST Tag

Synonyms

PP4R1, PPP4R1

Host/Source

E.coli

Product Type

Active Enzyme

Reactivity

Human

Applications

Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.

Size

20 µg

Price (USD)

$361

Background

MEG-1, also know as Serine/threonine phosphatase 4 regulatory subunit 1, PPP4R1 or PP4R1 is crucial to cellular function. The catalytic subunit of MEG-1 or protein phosphatase 4 (PP4C) is 65% identical to PP2AC at the amino acid level and has been placed in the type 2A family of phosphatases. MEG-1 has been highly conserved between species sharing 91% amino acid identity between human and Drosophila. MEG-1 is predominantly localized in the nucleus in rat brain and liver but is most highly expressed in testis. MEG-1 is an essential enzyme in the development of Drosophila embryos.

Immunogen

Recombinant enyzme produced in E. coli

Formulation

Provided in 25 mM Tris-HCl, 75 mM NaCl, pH 8.0, 0.05% Tween, 5 mM DTT and 50% glycerol

Customer Storage

Enzyme should be stored at -20°C. Enzyme should be kept on ice when dispensing

Target Molecular Weight

60.3 kDa

Database Links:

GenBankNM_002830Human

References

[1] Kloeker S., Wadzinski B.E.; Purification and identification of a novel subunit of protein serine/threonine phosphatase 4.; J. Biol. Chem. 274:5339-5347(1999).
[2] Wada T., Miyata T., Inagi R., Nangaku M., Wagatsuma M., Suzuki D., Wadzinski B.E., Okubo K., Kurokawa K.; Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells.; J. Am. Soc. Nephrol. 12:2601-2608(2001).
[3] Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.
Genes Dev. 2005 Apr 1;19(7):827-39.
[4] Kloeker S, Wadzinski BE. Purification and identification of a novel subunit of protein serine/threonine phosphatase 4. J Biol Chem. 1999 Feb 26;274(9):5339-47.