Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Sphingosine Kinase 2 Blocking Peptide

  • Product Code: X1642B
  • Size: 50 µg
  • Price (USD): $113

Cat #

X1642B		 Quantity:      

Data Sheet

Product Name

Sphingosine Kinase 2 Blocking Peptide

Synonyms

EC 2.7.1, SK 2, SPK 2, SPHK2, Gene name: SPHK2 or SPHK or SP

Product Type

Blocking Peptide

Applications

Antibody function blocking

Size

50 µg

Price (USD)

$113

Background

Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors). These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide raange of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).

Formulation

Provided in solution at 1 mg/ml in phosphate buffered saline.

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles