Sphingosine 1-Phosphate Phosphatase 2
- Product Code: X1637P
- Size: 100 µg
- Price (USD): $371
Cat #
Data Sheet
Product Name
Sphingosine 1-Phosphate Phosphatase 2
Synonyms
Sphingosine 1-Phosphate Phosphohydrolase
Host/Source
Rabbit
Isotype
Not applicable
Product Type
Antigen Immunoaffinity Purified Polyclonal
Reactivity
Human
Applications
Western Blot
Purification
Antigen Immunoaffiinity Purification
Size
100 µg
Price (USD)
$371
Background
Sphingosine 1-phosphate (S1P) is a highly bioactive lipid that has a myriad of biological effects both intracellularly as a second messenger and extracellularly by binding to the S1P(1-5)/G-protein-coupled receptors of the endothelial differentiation gene family. Intracellularly, at least two enzymes, sphingosine kinase (1 and 2) and S1P phosphatase, regulate the activity of S1P by governing the phosphorylation of S1P. SPPase2 is localized to the endoplasmic reticulum. The enzymatic activity and localization of SPPase2 are similar to SPPase1. The tissue expression of SPPase2 was different from that of SPPase1. SPPase2 is an important member of the SPPase family which play a role in attenuating intracellular S1P signaling.
Immunogen
Synthetic peptide derived from the sphingosine 1-phosphate phosphatase 2 protein.
Positive Control
Human brain lysate (Cat. No. X1633C)
Formulation
Provided as whole antiserum
Customer Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Database Links:
| SwissProt | Q8IWX5 | Human |
References
1. Mechtcheriakova D, et al. Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. Cell Signal. 2007 Apr;19(4):748-60. Epub 2006 Sep 30. Links2. Grey, A., et al. 'Osteoblastic Cells Express Phospholipid Receptors and Phosphatases and Proliferate in Response to Sphingosine 1-Phosphate.' Calcid Tissue Int. 2004
3. Pettus, B.J., et al. 'The sphingosine kinase 1/sphingosine 1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha.' FASEB J. 2003, 17, 1411-1421
4. Johnson, K.R., et al. 'Role of human sphingosine 1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine 1-phosphate levels and cell viability.' J. Biol. Chem. 2003, 278, 34541-34547
5. Cuvillier, O. 'Sphingosine in apoptosis signalling.' Biochim. Biophys. Acta 2002, 1585, 153-162
6. Ogawa, C., et al. 'Identification and characterization of a novel human sphingosine 1-phosphate phosphohydrolase, hSPP2.' J. Biol. Chem. 2003, 278, 1268-1272
7. Le Stunff, H., et al. 'Characterization of murine sphingosine 1-phosphate phosphohydrolase.' J. Biol. Chem. 2002, 277, 8920-8927
8. Birchwood, C.J., et al. 'Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation.' J. Biol. Chem. 2001, 276, 11712-11718
