Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Sphingosine 1-Phosphate Phosphatase 1

  • Product Code: X1636P
  • Size: 100 µg
  • Price (USD): $371

Cat #

X1636P		 Quantity:      

Data Sheet

Product Name

Sphingosine 1-Phosphate Phosphatase 1

Host/Source

Rabbit

Isotype

IgG

Product Type

Polyclonal Antibody

Reactivity

Human

Applications

Western Blot

Purification

Ammonium Sulfate Precipitation

Size

100 µg

Price (USD)

$371

Background

Sphingosine 1-phosphate (S1P) is a highly bioactive lipid that has a myriad of biological effects both intracellularly as a second messenger and extracellularly by binding to the S1P(1-5)/G-protein-coupled receptors of the endothelial differentiation gene family. Intracellularly, at least two enzymes, sphingosine kinase (1 and 2) and S1P phosphatase, regulate the activity of S1P by governing the phosphorylation of S1P. Regulation of hS1Pase1 with the resultant changes in cellular and secreted S1P has important implications in cell proliferation, angiogenesis and apoptosis.

Immunogen

Synthetic peptide derived from the sphingosine 1-phosphate phosphatase 1 protein.

Positive Control

Human brain lysate (Cat. No. X1633C)

Formulation

Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

49 kDa

Database Links:

SwissProtQ9BX95Human

References

1. Grey, A., et al. 'Osteoblastic Cells Express Phospholipid Receptors and Phosphatases and Proliferate in Response to Sphingosine 1-Phosphate.' Calcid Tissue Int. 2004 2. Pettus, B.J., et al. 'The sphingosine kinase 1/sphingosine 1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha.' FASEB J. 2003, 17, 1411-1421 3. Johnson, K.R., et al. 'Role of human sphingosine 1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine 1-phosphate levels and cell viability.' J. Biol. Chem. 2003, 278, 34541-34547 4. Cuvillier, O. 'Sphingosine in apoptosis signalling.' Biochim. Biophys. Acta 2002, 1585, 153-162 5. Ogawa, C., et al. 'Identification and characterization of a novel human sphingosine 1-phosphate phosphohydrolase, hSPP2.' J. Biol. Chem. 2003, 278, 1268-1272 6. Le Stunff, H., et al. 'Characterization of murine sphingosine 1-phosphate phosphohydrolase.' J. Biol. Chem. 2002, 277, 8920-8927 7. Birchwood, C.J., et al. 'Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation.' J. Biol. Chem. 2001, 276, 11712-11718