Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Protein Kinase C-Catalytic Fragment

  • Product Code: X1607RP
  • Size: 200 Units
  • Price (USD): $150

Cat #

X1607RP		 Quantity:      

Product Name

Protein Kinase C-Catalytic Fragment

Synonyms

2+and, PKC-M

Host/Source

Rat Brain

Product Type

Active Enzyme

Applications

Enzyme activity assay standard

Purification

Trypsin Digestion

Size

200 Units

Price (USD)

$150

Background

Protein kinase C (PKC) is a multifunctional protein kinase that plays a critical regulatory role in a wide variety of cellular signaling processes. It is an ubiquitous calcium and phospholipid-dependent protein kinase. At least 10 PKC isoforms are reported to exist which are classified as conventional (?, ?, ?), novel (?, ?, ?, ?, ?), and atypical (?, ?) isoforms (Ohno and Nishizuka, 2002). PKC is one of the three major protein kinases (including CaM Kinase II and PKA) that mediate cellular responses to second messengers. PKC regulates a number of cellular functions including neurotransmitter synthesis and release, gene expression, ion channel function and synaptic plasticity (Lu et al., 1999; Grosshans et al., 2002; Nishizuka, 1995). The catalytic fragment of PKC (PKC-M) does not require Ca 2+ or phosphatidylserine for its activity.

Immunogen

Prepared from rat brain PKC holoenzyme

Formulation

100 mM NaCl, 20 mM Tris-HCl, pH 7.5, 15 mM DTT, 1 mM ED

Customer Storage

Product should be stored at -70ºC. Aliquot to avoid freeze/thaw cycles