Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc. is now a US distributor for Nordic-Mubio products

Nordic-MUbio develops and manufactures high quality antibody reagents for use in R&D. All our products are manufactured according to strict ISO 9001 quality guidelines, and our focus is on developing antibodies targetting Cell Adhesion, Nuclear and Cytoskeletal Proteins.

Nordic-MUbio is one of the leading antibody companies developing antibodies for zebrafish research – we currently have over 50 antibodies validated for immunofluorescence in zebrafish.

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Latest References

Akazawa, Y., et al. "Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis" PLoS ONE 8(12): e82322

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Homa, N.J., et al. "Epstein-Barr Virus Induces Global Changes in Cellular mRNA Isoform Usage That Are Important for the Maintenance of Latency" J. Virol., 2013, 87, 12291-12301

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Exalpha Biologicals, Inc.

OGR1/GPR68

  • Product Code: X1600P
  • Size: 100 µg
  • Availability: In Stock In Stock
  • Price (USD): $438

Cat #

X1600P		 Quantity:      

Data Sheet

Product Name

OGR1/GPR68

Synonyms

GPR68; Ovarian Cancer G Protein-Coupled Receptor 1

Host/Source

Rabbit

Isotype

IgG

Product Type

Polyclonal Antibody

Reactivity

Human

Applications

Western Blot, IHC, Neutralization

Purification

Ammonium Sulfate Precipitation

Size

100 µg

Price (USD)

$438

Background

OGR1 (originally identified as GPR68) is a high-affinity receptor for sphingosylphosphorylcholine (SPC). SPC is a member of a class of bioactive lipids which regulate cellular functions. These functions include cell proliferation and growth inhibition, smooth muscle contration and wound healing. SPC also stimulated signalling pathways that induce tyrosine phosphorylation, activate MAP kinases and protein kinase C, modify ion channel activity and increase intracellular Ca2+ concentration. OGR1 is expressed in placenta, lung, liver, spleen, testis, small intestine and peripheral blood leukocytes. It is not found in thymus, ovary, colon, skeletal muscle, kidney or pancreas.

Immunogen

Recombinant protein derived from human OGR1 (GPR68) protein

Positive Control

OGR1 transfected cell lysate

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Product Image

Image Legend

Western blot analysis using OGR1 antibody on cells transfected with OGR1 protein at 10 µg/ml. Blot developed using Pierce?s SuperSignal West Femto Maximum Sensitvity Substrate.

Database Links:

SwissProtQ15743Human

References

1. Xu, Y., et al. 'Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.' Nature Cell Biol., 2, 261-267 (2000)

2. Singh, L.S., et al. ?Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer.? J. Natl. Cancer Inst., 99, 1313-1327 (2007)

3. Yang, M., et al. ?Expression of and Role for Ovarian Cancer G-protein-coupled Receptor 1 (OGR1) during Osteoclastogenesis? J. Biol. Chem., 281, 23598-23605 (2006)




Product Specific References


This product has been used in:

1. Iwai, K., et al. ?RGS18 Acts as a Negative Regulator of Osteoclastogenesis by Modulating the Acid-Sensing OGR1/NFAT Signaling Pathway? J. Bone Miner. Res. 22, 1612-1620 (2007) (Neutralization)