Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Sphingosine 1 Phosphate 3 Receptor (EDG-3) NT

  • Product Code: X1590P
  • Size: 100 µg
  • Price (USD): $399

Cat #

X1590P		 Quantity:      

Data Sheet

Product Name

Sphingosine 1 Phosphate 3 Receptor (EDG-3) NT


Endothelial cell differentiation gene 3 N-terminal; Sphingosine-1-Phosphate Receptor-3 (S1P3)



Product Type

Polyclonal Antibody




Western Blot


Ammonium Sulfate Precipitation


100 µg

Price (USD)



Endothelial cell differentation gene-3 (EDG3) belongs to a family of G-protein couple receptors whose ligands are lysophospholipids. The ligand for EDG3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family. They have been implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG3 is expressed in cardiovascular, leukocyte-containing and other tissues.


Synthetic peptide derived from the N terminal of the EDG3 (S1P3) protein.

Positive Control

RH7777 cells transfected with EDG3 (S1P3) protein


Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Database Links:



1. Goetzl EJ and An, S. Diversity of cellular receptors and functions for the lysophospholipid growth factos lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 1998: 12, 1589-98. 2. An, S., Goetzl, E.J., Lee, H. Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. Cell Biochem. Suppl. 1998: 30-31, 147-57.

Product Specific References

This product has been used in:

1. Licht, Tamar et al, 'Induction of pro-angiogenic signaling by a synthetic peptide derived from the scond intracellular loop of SIP3 (EDG3)' Blood 2003, 102, 6, 2099-2107 2. Sun, X., et al. 'Sphingosine-1-Phosphate Receptor-3 Is a Novel Biomarker in Acute Lung Injury.' American Journal of Respiratory Cell and Molecular Biology, Nov 2012, 47(5): 628-636.