Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

EGFR

  • Product Code: X1568M
  • Size: 100 µg
  • Price (USD): $361

Cat #

X1568M		 Quantity:      

Data Sheet

Product Name

EGFR

Host/Source

Mouse

Clone

H11

Isotype

IgG1

Product Type

Monoclonal Antibody

Reactivity

Human doens not react with mouse and rat. Others not known.

Applications

WB of Extracellular domain, FC, IF, IP (native only), IHC (Paraffin)

Purification

Protein A/G Chromatography

Size

100 µg

Price (USD)

$361

Background

EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-? (TGF-?), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Immunogen

Hybridoma produced by the fusion of splenocytes from mice immunized with HC2 20 d2 cells and mouse myeloma cells. Recognizes the extracellular domain

Positive Control

A431 cells or placenta or squamous cell carcinoma

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

170kDa (wild type)

Product Image

Image Legend

Immunohistochemical staining using EGFR antibody on formalin-fixed, paraffin embedded human squamous cell carcinoma of lung.

Database Links:

SwissProtP00533Human

References

1. Wikstrand CJ, et. al. 'Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas.' Cancer Res, 1995, 55(14):3140-8.