Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Sphingosine 1 Phosphate 4 Receptor (EDG8)

  • Product Code: X1487C
  • Size: 100 µl
  • Price (USD): $113

Cat #

X1487C		 Quantity:      

Data Sheet

Product Name

Sphingosine 1 Phosphate 4 Receptor (EDG8)

Synonyms

EDG8 (S1P5) Transfected Cell Positive Control Lysate

Product Type

Control Lysate

Reactivity

N/A

Applications

Western Blot

Size

100 µl

Price (USD)

$113

Background

Endothelial Cell Differentiation Gene-8 (EDG8 (S1P5)) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG8 (S1P5) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG8 (S1P5) is expressed in oligodendrocytes and fibrous astrocytes in the rat brain.

Formulation

Provided in 10% glycerol, 0.063 M Tris-HCl (pH 6.8), 2% SDS and 0.002% bromophenol blue, 5% 2-mercaptoethanol

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles