Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

ALK5 (Activin Receptor-Like Kinase 5)

  • Product Code: X1483P
  • Size: 250 µg
  • Price (USD): $210

Cat #

X1483P		 Quantity:      

Product Name

ALK5 (Activin Receptor-Like Kinase 5)

Host/Source

Sheep

Isotype

IgG

Product Type

Polyclonal Antibody

Reactivity

Chicken

Applications

Western Blot, Immunoprecipitation

Purification

Ammonium Sulfate Precipitation

Size

250 µg

Price (USD)

$210

Background

Specific for 56 kDa Activin Receptor-Like Kinase 5 (ALK5), a member of the superfamily of type I receptors for transforming growth factor-b (TGF-b). This receptor binds both activin and bone morphogenic proteins (BMPs).

Immunogen

Recombinant protein derived from the extracellular domain of the chicken ALK5 protein. Protein shares significant homology with the mouse, rat and human sequences.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

References

1. Baldwin, R.L., et al. 'Attenuated ALK5 receptor expression in human pancreatic cancer: correlation with resistance to growth inhibition.' Int. J. Cancer 1996, 67, 283-288 2. Bloom, B.B., et al. 'Structure and expression of the promoter for the R4/ALK5 human type I transforming growth factor-beta receptor: regulation by TGF-beta.' Biochim. Biophys, Acta 1996, 1312, 243-248 3. Callahan, J.F., et al. 'Identification of novel inhibitors of the transforming growth factor beta 1 (TGF-beta1) type 1 receptor (ALK5).' J. Med. Chem. 2002, 45, 999-1001