Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Heregulin alpha1 recombinant protein

  • Product Code: X1371RP
  • Size: 100 µl
  • Price (USD): $234

Cat #

X1371RP		 Quantity:      

Product Name

Heregulin alpha1 recombinant protein

Product Type

Recombinant Protein

Size

100 µl

Price (USD)

$234

Background

Heregulin (HRG) is a glycoprotein of 44kDa which binds to c-erbB-3 and c-erbB-4 receptors with low and high affinities, respectively. Heregulins constitute a family of mosaic proteins comprising of at least 12 members. They contain certain recognizable domains which include: an amino terminal (N-ter) region; an immunoglobulin- like motif (Ig); a glycosylated spacer sequence (glyco); an EGF-like motif (EGF), which is subdivided into ? and ? isoforms; a juxtamembrane region subdivided into isoforms 1-3; a hydrophobic transmembrane domain (TM); a common cytoplasmic tail (Cyto); and a variable-length cytoplasmic tail (a-c). Using this nomenclature, several isoforms of HRG are designated as HRG-?1, HRG-?2, HRG-?3, HRG-?1, HRG-?2, HRG-?3, HRG-?2b, etc. Note: Though the neuronal counterparts of heregulin, (ARIA and GGF), are similar they do not have the spacer sequence and have a variable N-terminal region. GGF II contains a putative kringle motif and a hydrophobic signal peptide in addition.

Positive Control

T47-D breast cancer cells

Formulation

Packaged in physiological saline, pH 7.4, with 0.2% BSA. Note that this product is supplied without Sodium azide or any other preservative.

Customer Storage

Product should be stored at -20º to -70ºC. Aliquot to avoid freeze/thaw cycles

References

1. Lupu, R., et al. (1995) Seminars in Cancer Biology, 6:135-145. 2. Holmes W, et al. (1992) Science 256:1205-1210. 3. Peles E, et al. (1992) Cell 69:205-216.