Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

14.3.3 Pan

  • Product Code: X1315M
  • Size: 100 µg
  • Price (USD): $234

Cat #

X1315M		 Quantity:      

Product Name

14.3.3 Pan

Host/Source

Mouse

Clone

1433P04

Product Type

Monoclonal Antibody

Purification

Protein A/G Chromatography

Size

100 µg

Price (USD)

$234

Background

14-3-3 pan recognizes the beta, gamma, sigma and zeta isoforms of 14.3.3. 14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins. 14-3-3 proteins bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein.

Immunogen

14.3.3 gamma recombinant protein of human origin.

Positive Control

HeLa cells.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

References

1. Laronga C, Yang HY, Neal C, Lee MH. Association of the cyclin-Dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression. J Biol. Chem 2000. 2. Baldin V. (2000)14-3-3 proteins and growth control. Prog cell cycle res. 4: 49-60 3. Skoulakis EM, Davis RL. (1998) 14-3-3 proteins in neuronal development. Mol. Neurobiol. 3, 269-284. 4. Roberts MR. (2000) Regulatory 14-3-3 protein-protein interactions in plant cells. Curr Opin Plant Biol 5: 400-405.