Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

14.3.3 gamma

  • Product Code: X1314M
  • Size: 100 µg
  • Price (USD): $234

Cat #

X1314M		 Quantity:      

Product Name

14.3.3 gamma

Host/Source

Mouse

Clone

1433G02

Product Type

Monoclonal Antibody

Purification

Protein A/G Chromatography

Size

100 µg

Price (USD)

$234

Background

Recognizes a protein of 28-33 kDa, identified as 14-3-3 gamma. This antibody is highly specific to 14.3.3 gamma and shows no cross-reaction with other isoforms of 14.3.3. 14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins. 14-3-3 proteins bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein. Expression of 14-3-3 gamma is higher in vascular smooth muscle cells and skeletal and heart muscle. In Alzheimer's disease and Down syndrome level of 14-3-3 gamma in brain increases significantly.

Immunogen

14.3.3 gamma recombinant protein of human origin.

Positive Control

HeLa cells.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

References

1. Fountoulakis M, Cairns N, Lubec G. (1999) Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer’s disease and Down syndrome J. Neural Transm Suppl. 57: 323-335. 2. Autieri MV, Haines DS, Romanic AM, Ohlstein EH. (1996) Expression of 14-3-3 gamma in injured arteries and growth factor- and cytokine stimulated human vascular smooth muscle cells. Cell Growth Differ. 11:1453-1460.