- Product Code: X1314M
- Size: 100 µg
- Price (USD): $234
Protein A/G Chromatography
Recognizes a protein of 28-33 kDa, identified as 14-3-3 gamma. This antibody is highly specific to 14.3.3 gamma and shows no cross-reaction with other isoforms of 14.3.3. 14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins. 14-3-3 proteins bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein. Expression of 14-3-3 gamma is higher in vascular smooth muscle cells and skeletal and heart muscle. In Alzheimer's disease and Down syndrome level of 14-3-3 gamma in brain increases significantly.
14.3.3 gamma recombinant protein of human origin.
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles