Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Lysophosphatidic Acid Receptor 3 (EDG-7)

  • Product Code: X1275MP
  • Size: 50 Tests
  • Price (USD): $438

Cat #

X1275MP		 Quantity:      

Data Sheet

Product Name

Lysophosphatidic Acid Receptor 3 (EDG-7)

Synonyms

Functional Endothelial Cell Differentiation Gene Receptor-7 (LPA3) Membrane Preparation

Product Type

Membrane Preparation

Reactivity

N/A

Applications

[35S]GTPgS Labeling

Size

50 Tests

Price (USD)

$438

Background

Endothelial Cell Differentiation Gene-7 (EDG-7) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-7 is lysophospholipid. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-7 is expressed in prostate as well as other tissues.

Formulation

Provided as a sterile solution in 50 mM HEPES containing 2 mM EDTA, 100 mM NaCl and 1 mM MgCl2 (pH 7.5)

Customer Storage

Product should be stored at -70ºC. Aliquot to avoid freeze/thaw cycles

References

1. Bandoh, K., et al. Molecular cloning and characterization of a novel human G-protein coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 1999, 274, 27776-27785 2. Im, D.S., et al. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. Mol. Pharmacol. 2000, 57, 753-759 3. Fang, X., et al. Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer. Ann. N.Y. Acad. Sci. 2000, 905, 188-208 4. Zheng, Y., et al. 'Lysophosphatidic acid receptor-selection effects on Jurkat T cell migration through a matrigel model basement membrane.' J. Immunol. 2001, 166, 2317-2322 5. Parrill, A.L., et al. 'Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.' J. Biol. Chem. 2000, 275, 39379-39384.