Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc. is now a US distributor for Nordic-Mubio products

Nordic-MUbio develops and manufactures high quality antibody reagents for use in R&D. All our products are manufactured according to strict ISO 9001 quality guidelines, and our focus is on developing antibodies targetting Cell Adhesion, Nuclear and Cytoskeletal Proteins.

Nordic-MUbio is one of the leading antibody companies developing antibodies for zebrafish research – we currently have over 50 antibodies validated for immunofluorescence in zebrafish.

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Latest References

Akazawa, Y., et al. "Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis" PLoS ONE 8(12): e82322

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Homa, N.J., et al. "Epstein-Barr Virus Induces Global Changes in Cellular mRNA Isoform Usage That Are Important for the Maintenance of Latency" J. Virol., 2013, 87, 12291-12301

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Exalpha Biologicals, Inc.

Sphingosine 1 Phosphate Receptor 1 (EDG-1)

  • Product Code: X1273MP
  • Size: 50 Tests
  • Availability: In Stock In Stock
  • Price (USD): $438

Cat #

X1273MP		 Quantity:      

Data Sheet

Product Name

Sphingosine 1 Phosphate Receptor 1 (EDG-1)

Synonyms

Functional Endothelial Cell Differentiation Gene Receptor-1 (S1P) Membrane Preparation

Product Type

Membrane Preparation

Reactivity

N/A

Applications

[35S]GTPgS Labeling

Size

50 Tests

Price (USD)

$438

Background

EDG1 (S1P1) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG1 (S1P1) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG1 (S1P1) is expressed in cardiovascular, leukocyte- containing and other tissues.

Formulation

Provided as a sterile solution in 50 mM HEPES containing 2 mM EDTA, 100 mM NaCl and 1 mM MgCl2 (pH 7.5)

Customer Storage

Product should be stored at -70°C. Aliquot to avoid freeze/thaw cycles

References

1. Tigyi, G., et al. 'Pharmacological characterization of phospholipid growth-factor receptors.' Ann N Y Acad Sci. 2000, 905, 34-53

2. Liu, Y., et al., Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J. Clin. Invest., 2000, 106, 951-961.

3. Nakajima, N., et al., Expression and characterization of edg-1 receptors in rat cardiomyocytes calcium deregulation in response to sphingosine-1-phosphate. Eur. J. Biochem., 2000, 267, 5679-5686.

4. Goetzl, E.J. and An, S., Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 2000, 12, 1589-1598.

5. Parrill, A.L., et al. 'Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.' J. Biol. Chem. 2000, 275, 39379-39384.