- Product Code: X1262M
- Size: 100 µg
- Price (USD): $249
Immunoprecipitation, ELISA, Immunohistochemistry (Frozen & Paraffin Sections), Western Blot
Protein A/G Chromatography
The human estrogen receptor has a molecular weight of 67 kDa and consists of 6 functional domains (domains A-F). Functional mapping of the estrogen receptor has determined a transcriptional promoting activity in the A/B domain. The hormone-binding domain (E domain) is located towards the carboxy terminal, whereas the DNA-binding domain (C domain) is found in the central portion of the molecule. It has been speculated that the presence in breast cancer cells of truncated forms of the estrogen receptor lacking the hormone-binding domain might promote the uncontrolled growth of the tumor.
Hybridoma produced by the fusion of splenocytes from mice immunized with purified estrogen receptors from calf uterus tumor and mouse myeloma cells.
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles