Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Eotaxin-Biotin

  • Product Code: X1249C
  • Size: 20 µg
  • Price (USD): $525

Cat #

X1249C		 Quantity:      

Product Name

Eotaxin-Biotin

Synonyms

C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11

Isotype

N/A

Product Type

Synthetic Protein

Applications

Activity Assay

Size

20 µg

Price (USD)

$525

Background

Eotaxin is a potent eosinophil chemoattractant which was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Microsequencing of the purified protein revealed the guinea pig eotaxin to be a member of the beta (CC) chemokine family of inflammatory and immunoregulatory cytokines. cDNA clones for guinea pig, mouse and human eotaxin have recently been isolated. Mouse eotaxin cDNA encodes a 97 amino acid protein from which the amino-terminal 23 amino acid are cleaved to generate the 74 amino acid mature mouse eotaxin. Mature mouse eotaxin is approximately 60% identical to mature human and guinea pig eotaxin. In addition, mouse eotaxin also shows high amino acid sequence identity to members of the MCP family. Mouse eotaxin is chemotactic for eosinophils, but not mononuclear cells or neutrophils. Eotaxin mRNA is expressed in a variety of tissues. The expression of eotaxin mRNA is induced in cultured endothelial cells in response to IFN-?. In addition, eotaxin mRNA is also induced in response to the transplantation of IL-4-secreting tumor cells. The CC chemokine receptor 3 (CCR3) has now been identified to be a specific human eotaxin receptor.

Formulation

Lyophilized

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Database Links:

SwissProtP51671Human

References

1. Rothenberg, M.E., et al. Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression. Proc. Natl. Acad. Sci. USA 1995, 92, 8960-8964 2. Quackenbush, E.J., et al. Eotaxin influences the development of embryonic hematopoietic progenitors in the mouse. J. Leukoc. Biol. 1997, 62, 661-666 3. Salcedo, R., et al. Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells. J. Immunol. 2001, 166, 7571-7578