Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Mip3b

  • Product Code: X1245C
  • Size: 20 µg
  • Price (USD): $450

Cat #

X1245C		 Quantity:      

Product Name

Mip3b

Synonyms

Macrophage Inflammatory Protein 3?

Product Type

Synthetic Protein

Applications

Activity Assay

Size

20 µg

Price (USD)

$450

Background

MIP-3b is related to other b chemokines, possessing 20-30% sequence identity with other b proteins. MIP-3b has been mapped to the 9p13 chromosome. This differs from other b proteins which are mapped to chromosome 17. MIP-3b is expressed in a variety of lymphoid tissues. and is down-regulated by the anti-inflammatory cytokine IL-10. Synthetic MIP-3b is chemotactic for cultured human lymphocytes and is a unique functional ligand for CCR-7. The CCR-7 receptor has been previously referred to as the Epstein-Barr virus-induced gene 1 (EBI1). CCR-7 is a chemokine receptor which is expressed in various lymphoid tissues and activated B and T lymphocytes. EBI1 is strongly up-regulated in B cells infected with Epstein-Barr virus and T cells infected with herpesvirus 6 or 7.

Formulation

Lyophilized

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

References

1. Yoshida, R. et al. 'Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7.' J. Biol. Chem. 1997: 272, 13803-13809 2. Gibejova, A., et al. 'Expression of Macrophage Inflammatory Protein (MIP)-3beta/CCL19 in pulmonary sarcoidosis.' Am. J. Respir. Crit. Care Med. 2003: epub ahead of print.