- Product Code: X1245C
- Size: 20 µg
- Price (USD): $450
Macrophage Inflammatory Protein 3?
MIP-3b is related to other b chemokines, possessing 20-30% sequence identity with other b proteins. MIP-3b has been mapped to the 9p13 chromosome. This differs from other b proteins which are mapped to chromosome 17. MIP-3b is expressed in a variety of lymphoid tissues. and is down-regulated by the anti-inflammatory cytokine IL-10. Synthetic MIP-3b is chemotactic for cultured human lymphocytes and is a unique functional ligand for CCR-7. The CCR-7 receptor has been previously referred to as the Epstein-Barr virus-induced gene 1 (EBI1). CCR-7 is a chemokine receptor which is expressed in various lymphoid tissues and activated B and T lymphocytes. EBI1 is strongly up-regulated in B cells infected with Epstein-Barr virus and T cells infected with herpesvirus 6 or 7.
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles