Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

MCP-1

  • Product Code: X1243C
  • Size: 20 µg
  • Price (USD): $450

Cat #

X1243C		 Quantity:      

Product Name

MCP-1

Synonyms

Human Monocyte Chemotactic Protein-1 Synthetic Chemokine

Product Type

Synthetic Protein

Applications

Activity Assay

Size

20 µg

Price (USD)

$450

Background

Monocyte chemotactic protein (MCP-1) is also known as monocyte chemotactic and activating factor (MCAF). It is the product of the human JE gene. The precursor form of MCP-1 consists of 99 amino acids with a signal peptide sequence consisting of 23 amino-terminal amino acids. The mature form of MCP-1 has 4 cysteine residues. The first two cysteine residues are in an adjacent position C-C, which characterizes MCP-1 as a member of the chemokine ? subfamily. MCP-1 is a nonglycosylated protein consisting of 76 amino acids with a molecular weight of 8700 daltons. MCP-1 mRNA expression can be induced in monocytes/macrophages, B lymphocytes, endothelial cells and astrocytoma cells by LPS. IL-1 will induce production of MCP-1 in fibroblasts, keratinocytes, hepatoma cells, and Type II pneumocytes. In vitro, MCP-1 will act on monocytes to initiate chemotaxis, induce superoxide anion release, induce the release of lysosomal enzymes and augment cytostatic activity. In vivo, MCP-1 will induce macrophage infiltration. The MCP-1 gene contains potential binding sites for several transcription factors, including AP-1, AP-2, NF-kB, and NF-IL6.

Formulation

Lyophilized

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

References

1. Conti, P. and DiGioacchino, M. 'MCP-1 and RANTES are mediators of acute and chronic inflammation.' Allergy Asthma Proc. 2001, 22, 133-137 2. Sozzani, S., et al. 'MCP-1 and CCR2 in HIV infection: regulation of agonist and receptor expression.' J. Leukoc. Biol. 1997, 62, 30-33