- Product Code: X1242C
- Size: 20 µg
- Price (USD): $415
Macrophage Inflammatory Protein-1 delta (MIP-1?), MIP-5, Synthetic Chemokine
Leukotactin-1 (Lkn-1), also known as Macrophage inflammatory protein 1 delta (MIP-1?), MIP-5, HCC-2, and NCC-3, is a novel human CC chemokine whose gene was mapped to human chromosome 17 adjacent to the HCC-1 gene. Lkn-1, together with mouse C10, mouse MIP-1? and human MPIF-1, constitute a subgroup of CC chemokines which contain six instead of four conserved cysteine residues. The two additional cysteine residues in Lkn-1 have been shown to form a third disulfide bond. Lkn-1 cDNA encodes a 113 amino acid precursor protein with a putative signal peptide of 21 aa residues that is cleaved to generate a 92 amino acid mature protein. In recombinant Lkn-1 preparations produced in insect cells and in yeast, amino-terminal truncations were found to have occurred. The major forms of Lkn-1 secreted by insect cells and yeast were reported to be proteins of 68 and 66 amino acids, respectively. The full length and the amino-terminal truncated forms of human Lkn-1 have been shown to be potent chemoattractants for monocytes and T-lymphocytes. These proteins can also chemoattract eosinophils and have been shown to induce calcium flux in human CCR-1 transfected cells. Additionally, Lkn-1 can suppress colony formation by human granulocyte-macrophage, erythroid, and multipotential progenitor cells stimulated by combinations of growth factors.
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles