Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Itac-Biotin

  • Product Code: X1241C
  • Size: 20 µg
  • Price (USD): $450

Cat #

X1241C		 Quantity:      

Product Name

Itac-Biotin

Synonyms

Itak, Biotin Conjugate, Human Synthetic Chemokine

Product Type

Synthetic Protein

Applications

Activity Assay

Size

20 µg

Price (USD)

$450

Background

Interferon-inducible T cell a chemoattractant (ITAC), which is also known as SCYB9B, ?-R1 or H174, is a non-ELR CXC chemokine. ITAC's cDNA encodes a 94 amino acid precursor with a 21 amino acid putative signal sequence which is cleaved to form the mature 73 amino acid protein. ITAC shares 36% and 37% sequence homology with IP-10 and MIG, respectively. ITAC is expressed at low levels in normal tissues including the thymus, spleen and pancreas. The expression of ITAC mRNA is radically up regulated in interferon-? and IL-1 stimulated astrocytes. Moderate increases in expression are also observed in stimulated monocytes. ITAC possesses potent chemoattractant activity for IL-2 activated T-cells and transfected cell lines expressing CXCR3 receptors, but not freshly isolated T-cells, neutrophils or monocytes. The gene which encodes ITAC has been mapped to chromosome 4.

Formulation

Lyophilized

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

References

1. Rani, M.R., et al. Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha. J. Biol. Chem. 1996, 271, 22878-22884 2. Luo, Y., et al. The CXC-chemokine, H174: expression in the central nervous system. J. Neurovirol. 1998, 4, 575-585 3. Rani, M.R., et al. Induction of beta-R1/I-TAC by interferon-beta requires catalytically active TYK2 J. Biol. Chem. 1999, 274, 1891-1897 4. Cole, K.E., et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J. Exp. Med. 1998, 187, 2009-2021 Product Specific References: 1. Dagan-Berger, M., et al. 'Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11.' Blood, 107, 3821-3831.