Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Fractalkine-Biotin

  • Product Code: X1239C
  • Size: 20 µg
  • Price (USD): $450

Cat #

X1239C		 Quantity:      

Product Name

Fractalkine-Biotin

Synonyms

Synthetic Human Fractalkine, Biotin-Conjugate

Product Type

Synthetic Protein

Applications

Activity Assay

Size

20 µg

Price (USD)

$450

Background

Fractalkine, also termed neurotactin, is a membrane-bound CX3C chemokine. The mature protein is part of a 397-amino acid precursor consisting of a chemokine domain (76 amino acids), a mucin stalk of 241 residues, a putative transmembrane domain (18 amino acids), and an intracellular tail of 37 amino acids. Within the chemokine domain the first two cysteine residues are separated by 3 amino acids. Fractalkine message is found at high concentrations in the brain, and also in kidney, lung and heart. Fractalkine is chemotactic for monocytes and may play a role in brain inflammation. Product provided is the 76 amino acid chemokine domain with a C-terminal biotin.

Formulation

Lyophilized

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

References

1. Bazan, J.F. et al. (1997) A new class of membrane-bound chemokine with a CX3C motif. Nature 385:640-644 2. Pan, Y. et al. (1997) Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 387:611-617 3. Harrison, J.K., et al. (1998) Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1- expressing microglia. Proc Natl Acad Sci U S A 95(18):10896-10901