Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Sphingosine 1 Phosphate Receptor 5 CT (EDG-8)

  • Product Code: X1228B
  • Size: 50 µg
  • Price (USD): $113

Cat #

X1228B		 Quantity:      

Data Sheet

Product Name

Sphingosine 1 Phosphate Receptor 5 CT (EDG-8)

Synonyms

Blocking peptide for use in Western blotting with Anti-EDG8 (S1P5) (CT) (Cat. No. X1094P)

Host/Source

N/A

Clone

N/A

Isotype

N/A

Product Type

Blocking Peptide

Applications

Antibody function blocking

Size

50 µg

Price (USD)

$113

Background

Endothelial Cell Differentiation Gene-8 (EDG8) (S1P5) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG8 (S1P5) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG8 (S1P5) is expressed in oligodendrocytes and fibrous astrocytes in the rat brain.

Formulation

Provided in solution at 1 mg/ml in phosphate buffered saline.

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles