Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc. is now a US distributor for Nordic-Mubio products

Nordic-MUbio develops and manufactures high quality antibody reagents for use in R&D. All our products are manufactured according to strict ISO 9001 quality guidelines, and our focus is on developing antibodies targetting Cell Adhesion, Nuclear and Cytoskeletal Proteins.

Nordic-MUbio is one of the leading antibody companies developing antibodies for zebrafish research – we currently have over 50 antibodies validated for immunofluorescence in zebrafish.

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Akazawa, Y., et al. "Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis" PLoS ONE 8(12): e82322

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Homa, N.J., et al. "Epstein-Barr Virus Induces Global Changes in Cellular mRNA Isoform Usage That Are Important for the Maintenance of Latency" J. Virol., 2013, 87, 12291-12301

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Exalpha Biologicals, Inc.

Ral B

  • Product Code: X1211
  • Size: 25 µg
  • Availability: In Stock In Stock
  • Price (USD): $283

Cat #

X1211		 Quantity:      

Data Sheet

Product Name

Ral B

Synonyms

RalB Recombinant G-Protein, G protein

Product Type

Recombinant Protein

Reactivity

Human

Applications

Affinity Binding

Size

25 µg

Price (USD)

$283

Background

RalB is a member of the Ras-like GTP binding protein family. Ras proteins provide a crucial link in the intracellular signalling cascades. Ras proteins are members of the small G protein family. These proteins are characterized by a molecular weight between 20 and 30 kDa, the ability to bind GTP or GDP and a low intrinsic GTPase activity. These proteins relay signals from the plasma membrane activated by receptor tyrosine kinases to the nucleus via a network of serine/threonine kinases. Ras proteins belong to a family of approximately 40 mammalian and 60 non-mammalian proteins. Ras proteins were first discovered as the hyperactive products of mutant Ras genes which promote cancer by disrupting the normal controls on cell proliferation and differentiation; about 30% of human cancers have mutations in a Ras gene. Ras and Ras-like proteins function as switches, cycling between 2 distinct conformational states, active when GTP is bound and inactive when GDP is bound. Affinity precipitation assays can be used to determine the activation status of Ras and Ras-like family members. This assay is based on the ability of the Ras family effector proteins to interact specifically with the activated GTP-bound form of their target GTPases.

Immunogen

Recombinant GST protein from E. Coli

Formulation

Provided in 50mM Tris (pH 7.5) solution containing 150 mM NaCl, 10 mM MgCl2, 1 mM DTT, 10% glycerol

Customer Storage

Product should be stored at -70°C. Aliquot to avoid freeze/thaw cycles

Database Links:

SwissProtP11234Human

References

1. Zhao, Z. & Rivkees, S.A., Tissue-specific expression of GTPase RalA and RalB during embryogenesis and regulation by epithelial-mesenchymal interaction. Mech. Dev. 2000, 97, 201-204

2. Bhullar, R.P. & Yang, S., Immunodetection of ralA and ralB GTP-binding proteins in various rat tissues and platelets. Mol. Cell Biochem. 1998, 179, 49-55

3. Jilkina, O. & Bhullar, R.P., Generation of antibodies specific for the RalA and RalB GTP-binding proteins and determination of their concentration and distribution in human platelets. Biochim. Biophys. Acta 1996, 1314, 157-166