Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Lysophosphatidic Acid Receptor 3 CT (EDG-7)

  • Product Code: X1183P
  • Size: 100 µg
  • Price (USD): $438

Cat #

X1183P		 Quantity:      

Data Sheet

Product Name

Lysophosphatidic Acid Receptor 3 CT (EDG-7)

Synonyms

Endothelial cell differentiation gene 7 C-terminal; Lysophosphatidic Acid Receptor-4 (LPA3)

Host/Source

Rabbit

Isotype

IgG

Product Type

Polyclonal Antibody

Reactivity

Human

Applications

Western Blot

Purification

Ammonium Sulfate Precipitation

Size

100 µg

Price (USD)

$438

Background

Endothelial Cell Differentiation Gene-7 (EDG-7) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-7 is lysophospholipid. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-7 is expressed in prostate as well as other tissues.

Immunogen

Antibody raised against a unique synthetic peptide derived from the C-terminal of the human EDG7 protein.

Positive Control

RH7777 cells transfected with EDG7 protein (Cat. No. X1220C)

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

40

Product Image

Image Legend

Western blot analysis using anti-EDG-7 CT antibody on RH7777 cell lysates transfected with full length human EDG-7 using Pierce Femto Signal substrate.

Database Links:

SwissProtQ9UBY5Human

References

1. Bandoh, K., et al. Molecular cloning and characterization of a novel human G-protein coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 1999, 274, 27776-27785 2. Im, D.S., et al. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. Mol. Pharmacol. 2000, 57, 753-759 3. Fang, X., et al. Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer. Ann. N.Y. Acad. Sci. 2000, 905, 188-208