Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc.

Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6)

  • Product Code: X1182P
  • Size: 100 µg
  • Price (USD): $438

Cat #

X1182P		 Quantity:      

Data Sheet

Product Name

Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6)

Synonyms

Endothelial cell differentiation gene 6 C-terminal; Sphingosine-1-Phosphate Receptor-4 (S1P-4)

Host/Source

Rabbit

Product Type

Polyclonal Antibody

Reactivity

Human

Applications

Western Blot

Purification

Ammonium Sulfate Precipitation

Size

100 µg

Price (USD)

$438

Background

EDG-6 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-6 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-6 is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG-6 receptor is the sphingosine 1-phosphate receptor-4 (S1P-4).

Immunogen

Synthetic peptide derived from the C-terminal of the EDG-6 receptor

Positive Control

RH7777 cells transfected with EDG6 protein (Cat. No. X1311C)

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

45

Product Image

Image Legend

Western blot analysis using EDG6 (S1P4) antibody on RH7777 cells transfected with EDG6 (S1P4) protein in the presence (1) and absence (+) of specific blocking peptide.

Database Links:

SwissProtO95977Human

References

1. Yamazaki, Y., et al. 'EDG-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway.' Biochem. Biophys. Res. Commun. 2000, 268, 583-589. 2. Van Brocklyn, J.R., et al. 'Sphingosine 1-phosphate is a ligand for the G protein-coupled receptor EDG-6.' Blood 2000, 95, 2624-2629. 3. Takuwa, Y., et al. 'Subtype-specific, differential activities of the EDG family receptors for sphingosine 1-phosphate, a novel lysophospholipid mediator.' Mol. Cell Endocrinol. 2001, 177, 3-11.


Product Specific References


This product has been used in:

1. Dorsam, Glenn et al, 'Transducion of Multiple Effects of Sphingosine 1-Phosphate (S1P) on T Cell Function by the S1P1 G Protein-Coupled Receptor ' The Journal of Immunology 2003, 171, 7, 3500-3507