Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc.

Amyloid Precursor Protein (APP) (CT)

  • Product Code: X1134P
  • Size: 100 µg
  • Price (USD): $399

Cat #

X1134P		 Quantity:      

Data Sheet

Product Name

Amyloid Precursor Protein (APP) (CT)

Synonyms

Alzheimer disease amyloid protein, ABPP. APPI, PreA4, Cerebral vascular amyloid peptide

Host/Source

Rabbit

Isotype

IgG

Product Type

Polyclonal Antibody

Reactivity

Human, Mouse, Rat

Applications

Western Blot

Purification

Antigen Immunoaffiinity Purification

Size

100 µg

Price (USD)

$399

Background

Accumulation of the amyloid-? peptide (A?) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The ??amyloid protein precursor (APP) is cleaved by ??secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for ??secretase to generate the 4 kDa amyloid-? peptide (A?), which is deposited in the brains of all suffers of Alzheimer's disease.

Immunogen

Synthetic peptide corresponding to amino acids 737 to 751 of human amyloid A4 protein precursor (APP) or 85 to 99 of the C99 generated by ? secretases. This sequence is identical to those of monkey, mouse, rat, chicken and a variety of other species.

Positive Control

Murine brain lysate

Formulation

Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

120

Product Image

Image Legend

Western blot analysis using APP (CT) antibody (Cat. No. X1134P) on mouse (1) and rat (2) brain tissue lysate.

Database Links:

SwissProtP05067Human

References

1. Ponte, P., et al. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 1988, 331, 525-527. 2. Selkoe, D.J. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell Biol. 1994, 10, 373-403