Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Acinus (IN)

  • Product Code: X1104P
  • Size: 100 µg
  • Price (USD): $383

Cat #

X1104P		 Quantity:      

Data Sheet

Product Name

Acinus (IN)

Synonyms

Apoptotic chromatin condensation inducer in the nucleus, ACINUS, KIAA0670

Host/Source

Rabbit

Isotype

IgG

Product Type

Polyclonal Antibody

Reactivity

Human

Applications

Western Blot

Purification

Antigen Immunoaffiinity Purification

Size

100 µg

Price (USD)

$383

Background

Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE (1). A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS' (2).

Immunogen

Synthetic peptide (DTSENRPENDVPEPP) corresponding to amino acids 775 to 789 of human AcinusL, 48 to 62 of human AcinusS’, or 17 to 31 of human AcinusS, which differ from those of mouse Acinus by one amino acid (2).

Positive Control

K562 cell lysate

Formulation

Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

220

Product Image

Image Legend

Western blot analysis using anti-Acinus (IN) antibody at 1 µg/ml on K562 cell lysate.

Database Links:

SwissProtQ9UKV3Human

References

1. Condensed matter in cell death. Zamzami, N and Kroemer, G. , Nature, 1999 , 401, 127-8 2. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Sahara S, et al., Nature, 1999, 401, 168-73