Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Matrix Metalloproteinase 13 (MMP13) (Truncated Latent Form)

  • Product Code: X1101
  • Size: 100 Tests
  • Price (USD): $395

Cat #

X1101		 Quantity:      

Product Name

Matrix Metalloproteinase 13 (MMP13) (Truncated Latent Form)

Synonyms

Recombinant Human Pro-Collagenase, Truncated form derived from the C-Terminal, Latent Form

Product Type

Recombinant Protein

Applications

Enzyme Standard

Size

100 Tests

Price (USD)

$395

Background

The collagenases are members of the matrix metalloproteinase (MMPs) family and at least three distinct forms (MMP-1, MMP-8 and MMP-13) have been identified. Collagenases are produced by many myeloid and non-myeloid cell types. Importantly, collagenase production has been found to increase in inflammation and also in tumor metastasis. Although the collagenases degrade collagen types I, II and III, their substrate specificity varies depending upon their role in physisological and pathological turnover of collagen. This pro-collagenase can be used as a standard for assaying MMP-13 or for screening of collagenase inhibitors.

Formulation

Provided as 0.05M Tris-HCl buffer, pH 7.5 containing 0.2M NaCl, 5 mM CaCl2 20 µM ZnSO4 and 0.1% BSA

Customer Storage

Product should be stored at -70ºC. Aliquot to avoid freeze/thaw cycles

References

1. Bickett, D.M., et al. A high throughput fluorogenic substrate for interstitial collagenase (MMP-1) and gelatinase (MMP-9). Anal. Biochem. 1993, 212, 58-64 2. Exalpha's MMP-13 Assay Kit Manual (Cat. No. X1097K)