Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

KSHV/HHV8 (cyclin)

  • Product Code: F105P
  • Size: 250 µg
  • Price (USD): $249

Cat #

F105P		 Quantity:      

Data Sheet

Product Name

KSHV/HHV8 (cyclin)

Synonyms

HHV8cyclin

Host/Source

Sheep

Isotype

IgG

Product Type

Polyclonal Antibody

Applications

Immunoprecipitation

Purification

Ammonium Sulfate Precipitation

Size

250 µg

Price (USD)

$249

Background

Human herpervirus-8 (HHV-8) cyclin is a component of the HHV-8 virus particle. HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma.

Immunogen

Inclusion Bodies from E. Coli expressing his-tagged full length human cyclin G2 protein.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

28.1

Database Links:

SwissProtO40946Human

References

Carbone, A., et al. 'Proliferation in HHV-8-positive primary effusion lymphomas is associated with expression of HHV-8 cyclin but independent of p27(kip1).' Am. J. Pathol. 2000, 156, 1209-1215 Product Specific References: 1. Godfrey, A., et al. 'Inhibiting primary effusion lymphoma by leniviral vectors encoding short hairpin RNA.' Blood, 2005, 105, 2510-2518. 2. Sugaya, M., et al. 'Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter.' Blood, 2005, 105, 2356-2363. 3. Jarviluoma, A., et al. 'KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas.' Blood, 2004, 104, 3349-3354.


Product Specific References


This product has been used in:

1. Jarviluoma, Annika et al, 'KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas' Blood 2004, 104, 10, 3349-3354