Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

bax (universal)

  • Product Code: A105M
  • Size: 100 µg
  • Price (USD): $244

Cat #

A105M		 Quantity:      

Data Sheet

Product Name

bax (universal)

Synonyms

ubax

Host/Source

Mouse

Clone

6A7

Isotype

IgG1

Product Type

Monoclonal Antibody

Reactivity

Human, Mouse, Rat

Applications

Immunoprecipitation

Purification

Protein A/G Chromatography

Size

100 µg

Price (USD)

$244

Background

The immunogen for the anti-universal bax was a synthetic peptide corresponding to amino acids 12 to 24 of the human bax sequence. Bax expression is associated with cell death regulation. The ratio of bax to other bcl-2 family members is believed to regulate apoptosis. Clone 6A7 is conformation dependant and will recognize only detergent treated bax protein and not the native form.

Immunogen

A synthetic peptide corresponding to amino acids 12 to 24 of the human bax sequence

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

21.2

Database Links:

SwissProtQ07812Human

References

1. Y.T. Hsu et. al. (1997) J. Biol. Chem., 272(21): 13829-13834

2. Y. T. Hsu et. al (1997) Proc. Natl. Acad. Sci. USA, 94: 3668-3672

3. Smoot, R.L., et al (2010) Cancer Res., 70, 1960-1969


Product Specific References


This product has been used in:

1. Lau, E., et al. ‘PKCε regulates ATF2 availability to alter mitochondrial permeability following genotoxic stress.’ Cell, 148, 543-555 (2012)
2. Cazanave, S.C., et. ‘JNK1-dependent PUMA Expression Contributes to
Hepatocyte Lipoapoptosisal.‘
3. Akazawa, Y., et al. ‘Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis.’ PLoS One, 8, e82322 (2013)