Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc. is now a US distributor for Nordic-Mubio products

Nordic-MUbio develops and manufactures high quality antibody reagents for use in R&D. All our products are manufactured according to strict ISO 9001 quality guidelines, and our focus is on developing antibodies targetting Cell Adhesion, Nuclear and Cytoskeletal Proteins.

Nordic-MUbio is one of the leading antibody companies developing antibodies for zebrafish research – we currently have over 50 antibodies validated for immunofluorescence in zebrafish.

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Akazawa, Y., et al. "Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis" PLoS ONE 8(12): e82322

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Homa, N.J., et al. "Epstein-Barr Virus Induces Global Changes in Cellular mRNA Isoform Usage That Are Important for the Maintenance of Latency" J. Virol., 2013, 87, 12291-12301

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Exalpha Biologicals, Inc.

COX II (cyclooxygenase II)

  • Product Code: A090M
  • Size: 100 µg
  • Availability: In Stock In Stock
  • Price (USD): $258

Cat #

A090M		 Quantity:      

Data Sheet

Product Name

COX II (cyclooxygenase II)

Synonyms

COXII, mouse anti human cyclooxygenase II, COX II, COX-II

Host/Source

Mouse

Clone

AS66

Isotype

IgG1

Product Type

Monoclonal Antibody

Reactivity

Human

Applications

Western Blot

Purification

Protein A/G Chromatography

Size

100 µg

Price (USD)

$258

Background

Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the conversion of arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG) D2, PGE2, PGF2a, PGI2 and Thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. There are two enzymes of COX, COX-1 and COX-2. COX-1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins, which inhibit gastric secretion. It can be induced in monocytes, macrophages and other cells. It is induced as part of the inflammatory response by IL-1beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX-2. COX-2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to the action of prostaglandins produced by COX-2.

Immunogen

Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with human recombinant COX2 protein and mouse myeloma cells.

Positive Control

EHY-926 endothelial cell lysate. Specificity: raised to human recombinant COX 2. Zero percent cross-reactivity to human recombinant COX1 by ELISA.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

69.0

Database Links:

SwissProtP35354Human

Product Specific References


This product has been used in:

1. Kaneshiro, Y., et al, 'Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats' Kidney International 2006, 70, , 641-646