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VEGF-D, rat


Catalogue number: VEGD02

Units200 µg
HostRabbit
Application ELISA
IHC not tested
WB (red. cond.)
Background
The polyclonal antibody against VEGF-D is well suited to detect rat VEGF-D in body fluids, tissues and culture media. VEGFs (Vascular Endothelial Growth Factors) are a group of homodimer glycoproteins. The subunits are linked by disulfide bonds. (MW reduced form 18-24 kDa). VEGFs are involved in angiogenesis during embryogenesis and in tumour progression and generation of metastasis. They possess mitogenic characteristics and specifically increase the permeability of endothelia in blood vessels. Rat VEGF-D, no reactivity with VEGF-A and -C.

Positive Control
Metastasing tumours of different origin

Immunogen
Recombinant rat delta-N-delta-C VEGF-D (native protein)

Purification Method
Protein A purified IgG lyophilised from PBS pH 7.4 without preservative

Working Concentration
(lyophilisate)

Concentration
200 µg

Product
Protein A purified IgG lyophilised from PBS pH 7.4 without preservative

Applications
ELISA, WB (red. cond.), IHC not tested

Cross Reactivity
Rat, cross-reaction with mouse and human

Storage
-20°C

References
1. Fitz LJ, Morris JC, Towler P, Long A, Burgess P, Greco R, Wang J, Gassaway R, Nickbarg E, Kovacic S, Ciarletta A, Giannotti J, Finnerty H, Zollner R, Beier DR, Leak LV, Turner KJ, Wood CR. Characterization of murine Flt4 ligand/VEGF-C. Oncogene. 1997 Jul 31;15(5):613-8. 2. Gu W, Brannstrom T, Jiang W, Bergh A, Wester P. Vascular endothelial growth factor-A and -C protein up-regulation and early angiogenesis in a rat photothrombotic ring stroke model with spontaneous reperfusion. Acta Neuropathol (Berl). 2001 Sep;102(3):216-26. 3. Tille JC, Wang X, Lipson KE, McMahon G, Ferrara N, Zhu Z, Hicklin DJ, Sleeman JP, Eriksson U, Alitalo K, Pepper MS. Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro. Exp Cell Res. 2003 May 1;285(2):286-98. 4. Krishnan J, Kirkin V, Steffen A, Hegen M, Weih D, Tomarev S, Wilting J,Sleeman JP. Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats. Cancer Res. 2003 Feb 1;63(3):713-22. 5. Weich HA, Bando H, Brokelmann M, Baumann P, Toi M, Barleon B, Alitalo K, Sipos B, Sleeman J. Quantification of vascular endothelial growth factor-C (VEGF-C) by a novel ELISA. J Immunol Methods. 2004 Feb 15;285(2):145-55.

Caution
These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

Safety Datasheet(s) for this product:

VEGF-D, rat

$564.00

SKU: VEGD02 Categories: ,

Brand

Contact us

Exalpha Biologicals, Inc.
2 Shaker Road, Unit B101
Shirley, MA 01464
Phone: 978-425-1370
Email: info@exalpha.com

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