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VEGF-A, pan-specific


Catalogue number: VEGA01

Units100 µg
HostRabbit
Application ELISA
IHC not tested
WB (red. cond.)
Background
VEGF-A is exprimed as 4 isoforms, the smaller ones (VEGF 121 and VEGF 165) are secretory proteins, while the larger forms (VEGF 189 and VEGF 206) remain associated with the cell walls. VEGFs (Vascular Endothelial Growth Factors) are a group of homodimer glycoproteins. The subunits are linked by disulfide bonds. (MW reduced form 18-24 kDa). VEGFs are involved in angiogenesis during embryogenesis and in tumour progression and generation of metastasis. They possess mitogenic characteristics and specifically increase the permeability of endothelia in blood vessels. VEGF-A isoforms in human, mouse and rat, .

Positive Control
Metastasing tumours of different origin

Immunogen
Highly purified human N-terminal VEGF-A (20 aa peptide)

Purification Method
Protein A purified IgG lyophilised from PBS pH 7.4 without preservative

Working Concentration
(lyophilisate) 5-10 µg/ml (WB), 0.5-2 µg/ml (dir. ELISA)

Concentration
100 µg

Product
Protein A purified IgG lyophilised from PBS pH 7.4 without preservative

Applications
ELISA, WB (red. cond.), IHC not tested

Cross Reactivity
Human, Mouse, Rat

Storage
-20°C

References
1. Gu W, Brannstrom T, Jiang W, Bergh A, Wester P. Vascular endothelial growth factor-A and -C protein up-regulation and early angiogenesis in a rat photothrombotic ring stroke model with spontaneous reperfusion. Acta Neuropathol (Berl). 2001 Sep;102(3):216-26. 2. Tille JC, Wang X, Lipson KE, McMahon G, Ferrara N, Zhu Z, Hicklin DJ, Sleeman JP, Eriksson U, Alitalo K, Pepper MS. Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro. Exp Cell Res. 2003 May 1;285(2):286-98.

Caution
These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

Safety Datasheet(s) for this product:

VEGF-A, pan-specific

$322.00

SKU: VEGA01 Categories: ,

Brand

Contact us

Exalpha Biologicals, Inc.
2 Shaker Road, Unit B101
Shirley, MA 01464
Phone: 978-425-1370
Email: info@exalpha.com

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