Sphingomyelin Synthase 1 (SMS1)Catalogue number: X2312B
|Product Type||Blocking Peptide|
Sphingomyelin Synthase is a bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) in addition to performing the inverse reaction. The direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. It directly and specifically recognizes the choline head group on the substrate. It also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. It may not function strictly as a SM synthase and is inhibited by bacterial PC-phospholipase C inhibitor D609. It is localized to Golgi apparatus; Golgi membrane; multi-pass membrane protein. It can be possibly present on the brain, heart, kidney, liver, muscle and stomach.
Synonyms: SMS1, Sphingomyelin synthase 1,Transmembrane protein 23, Medulla oblongata-derived protein, Protein Mob
Immunogen: Synthetic peptide derived from human SMS1 protein
Product Form: Unconjugated
Formulation: Provided as solution in phosphate buffered saline
Concentration: See vial for concentration
For use with SMS1 polyclonal antibodies (Cat. No. X2065P and X1701P).
Functional Analysis: Western Blotting
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: Products are stable for one year from purchase when stored properly
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
1. Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC Identification of a family of animal sphingomyelin synthases. EMBO J. 2004 Jan 14;23(1):33-44. Epub 2003 Dec 18.
Database Name: UniProt
Accession number: Q86VZ5
Species Accession: Human
Sphingomyelin Synthase 1 (SMS1)