SMO (Smoothened Homolog)Catalogue number: X2377B
|Product Type||Blocking Peptide|
SMO is a G protein-coupled receptor (GPCR) that putatively associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. The binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). In basal cell carcinoma there are two somatic mutations SMO, D473-> H473 and R562 ->Q562.
Synonyms: Smoothened homolog [Precursor], SMO, Gx protein, SMO, SMOH
Immunogen: peptide immunogen
Product Form: Unconjugated
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
Concentration: See vial for concentration
For use with SMO polyclonal antibodies (Cat. No. X2333P & X2376P).
Functional Analysis: Western Blotting
Positive Control: Brain
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: Products are stable for one year from purchase when stored properly
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Database Name: UniProt
Accession number: Q99835 (Human)
Species Accession: Human
Safety Datasheet(s) for this product:
SMO (Smoothened Homolog)