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Sheep anti-Cytochrome C


Catalogue number: A195P

ClonePolyclonal
Product Type Primary Antibodies
Units200 µl
HostSheep
Species reactivity Dog
Human
Rabbit
Rat
Application Immunohistochemistry
Immunoprecipitation
Western Blot
Background
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.

Positive Control
Rat1 cell line; Mitochondrion matrix

Immunogen
Full length recombinant Cytochrome

Purification Method
Whole Antiserum, no purification

Storage
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Safety Datasheet(s) for this product:

Sheep anti-Cytochrome C

$235.00

SKU: A195P Categories: ,

Brand

Contact us

Exalpha Biologicals, Inc.
2 Shaker Road, Unit B101
Shirley, MA 01464
Phone: 978-425-1370
Email: info@exalpha.com

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