LNX1Catalogue number: X2341B
|Product Type||Blocking Peptide|
LNX1 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65
Synonyms: Numb-binding protein 1; Ligand of Numb-protein X 1
Immunogen: Synthetic peptide derived from the human LNX1 protein.
Product Form: Unconjugated
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
Concentration: See vial for concentration
For use with LNX1 polyclonal antibodies (Cat. No. X2316P & X2340P).
Functional Analysis: Western Blotting
Positive Control: Protein expressed in heart, placenta, kidney, pancreas and brain.
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: Products are stable for one year from purchase when stored properly
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
1. Armbruester, V., et al. 'Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X.; J. Virol. 78:10310-10319(2004). 2. Sollerbrant, K., et al. 'The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX).; J. Biol. Chem. 278:7439-7444(2003). 3. Xie, Y., et al. 'Identification of a human LNX protein containing multiple PDZ domains.; Biochem. Genet. 39:117-126(2001).
Database Name: UniProt
Accession number: Q8TBB1
Species Accession: Human
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