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Sheep anti Human Guanalyate Kinase (PDZ 4-5) (MAGI)

Catalogue number: K110P

Product Type Polyclonal Antibody
Units250 µg
Species reactivity Human
Application Western Blot

Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These guanylate kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are made up of an N-terminal guanylate kinase domain, followed by a WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, which is then followed by 6 PDZ domains.

Synonyms: Sheep anti-Membrane-associated guanylate cyclase of inverted orientation-3, PSD95 DiscsLarge Z01 domains 4-5


Immunogen: Recombinant protein corresponding to PDZ domains 4-5 of MAGI-3.


Product Form: Unconjugated

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide

Purification Method: Ammonium Sulfate Precipitation

Concentration: See vial for concentration

Antibody detects MAGI-3 by Western blot at 1-10 µg/ml. Detects a 130 kDa band in cells transfected with full-length MAGI-3 protein. Optimal concentration should be evaluated by serial dilutions.

Functional Analysis: Western Blotting

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Product Stability: Products are stable for one year from purchase when stored properly

Shipping Conditions: Ship at ambient temperature, freeze upon arrival

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

1. Wu, Y., et al. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. J. Biol. Chem. 2000, 275, 21477-21485

Protein Reference(s)

Database Name: UniProt

Accession number: Q9H2V6

Safety Datasheet(s) for this product:
Sodium Azide

Sheep anti Human Guanalyate Kinase (PDZ 4-5) (MAGI)



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