FLAPCatalogue number: X2351B
|Product Type||Blocking Peptide|
Seems to be required for the activation of 5-LO (5-lipoxygenase). Could play an essential role in the transfer of arachidonic acid to 5-LO. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Genetic variations in FLAP may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Synonyms: FLAP; Arachidonate 5-lipoxygenase-activating protein; MK 886 binding protein
Immunogen: Synthetic peptide derived from human FLAP protein.
Product Form: Unconjugated
Formulation: Provided as solution in phosphate buffered saline
Concentration: See vial for concentration
For use with FLAP polyclonal antibodies (Cat. No. X2318P & X2350P).
Functional Analysis: Western Blotting
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: Products are stable for one year from purchase when stored properly
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
1. Dixon, R.A.F., et al. 'Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis.; Nature 343:282-284(1990). 2. Helgadottir, A., et al. 'The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.; Nat. Genet. 36:233-239(2004).
Database Name: UniProt
Accession number: P20292 (Human)
Species Accession: Human