Catalogue number: X2337B
F-box and WD-40 domain protein 7, FBXW7, CDC4
|Product Type||Blocking Peptide|
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Widely expressed in most human tissues.
Synthetic peptide dervied from the human FBXW7 protein
See vial for concentration
Provided as solution in phosphate buffered saline with 0.08% sodium azide
For use with FXBW7 polyclonal antibodies (Cat. No. X2314P & X2336P).
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Ship at ambient temperature, freeze upon arrival
Products are stable for one year from purchase when stored properly
1. Strohmaier, H., et al. 'Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.; Nature 413:316-322(2001). 2. Moberg, K.H., et al. 'Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines.; Nature 413:311-316(2001).
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Safety Datasheet(s) for this product: