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EDG8 (S1P5)


Catalogue number: X1487C

Synonyms
EDG8 (S1P5) Transfected Cell Positive Control Lysate

Product Type Control Lysate
Units100 µl
Application Western Blot
Product Form
Unconjugated

Background
Endothelial Cell Differentiation Gene-8 (EDG8 (S1P5)) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG8 (S1P5) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG8 (S1P5) is expressed in oligodendrocytes and fibrous astrocytes in the rat brain.

Concentration
See vial for concentration

Formulation
Provided in 10% glycerol, 0.063 M Tris-HCl (pH 6.8), 2% SDS and 0.002% bromophenol blue, 5% 2-mercaptoethanol

Functional Analysis
Western Blotting

Applications
Optimal concentration should be evaluated by serial dilutions.

Storage
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Ship Conditions
Ship at ambient temperature, freeze upon arrival

Product Stability
Products are stable for one year from purchase when stored properly

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

Safety Datasheet(s) for this product:

EDG8 (S1P5)

$119.00

SKU: X1487C Categories: ,